Navigating the Cellular Landscape: NMN as a Potential Remedy in Chronic Hepatitis B
A groundbreaking study from the University of Parma reveals the link between mitochondrial dysfunction, oxidative stress, and compromised CD8 T cells in chronic hepatitis B. Mitochondrial dysfunction leads to increased DNA damage in CD8 T cells, crucial in fighting the virus. CD38-mediated NAD+ depletion is identified as a key factor in CD8 T cell dysfunction. NMN supplementation and CD38 inhibition show promise in restoring CD8 T cell function, offering hope for intervention in chronic hepatitis B. With 296 million chronic HBV infections globally causing 820,000 deaths annually, this research provides insights into addressing a significant global health risk.
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